Axin-1 is a protein that in humans is encoded by the AXIN1 gene. [5] This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a …

Axin is known to have an important role in the degradation of β-catenin in the Wnt pathway. Here, we reveal a new function of Axin at the centrosome. Axin was localized to the centrosome in …

Here, we examine the role of different Axin domains in the effects on axis formation and β-catenin levels. We find that the regulators of G-protein signaling domain (major APC-binding site) and …

Oct 27, 2023 · Axin (also known as AXIN1) is a central negative regulator of the proto-oncogenic Wnt/β-catenin signaling pathway, as axin condensates provide a scaffold for the assembly of a …

Anti-FLAG staining for FLAG-Smad3 (green) and anti-Axin antibody staining for Axin (red) followed by Alexa Fluor 488 and 568, respectively, were performed in transfected HepG2 cells. …

Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a normal cellular state. Mutations inactivating the APC …

Nov 8, 2010 · Both PML and the key Wnt signaling regulator AXIN regulate p53-dependent apoptosis in response to DNA damage. However, how the two major tumor suppressors …

May 15, 2000 · The Axin‐RGS–SAMP3 complex is superimposed on the structure of the RGS4–G iα complex. Axin‐RGS is red, SAMP3 is blue, RGS4 is light gray and G iα is dark gray. The …

Axin is known to have an important role in the degradation of b-catenin in the Wnt pathway. Here, we reveal a new function of Axin at the centrosome. Axin was localized to the centrosome in …

Sep 18, 2019 · The paralogous scaffold proteins axin and conductin/axin2 are key factors in the negative regulation of the Wnt pathway transcription factor β-catenin, thereby representing …