We have explored the possibility that the scaffold protein Axin, which plays a central role in axis formation and perhaps in tumorigenesis also exerts a function in the MAPK pathway. It is …

Apr 10, 2012 · In melanoma, increased MAPK signaling stabilizes Axin, which inhibits Wnt signaling. RTK, receptor tyrosine kinase.

Dec 3, 1999 · Here we show that overexpression of Axin in human embryonic kidney 293T cells leads to differential activation of MAPK, with robust induction for c-Jun NH 2-terminal …

Axin is a multidomain protein that is fundamental and operates as a scaffold in Wnt signaling . Axin binds to MAP3K1/4 before activating the p38/JNK MAPK downstream.

Here we show that overexpres-sion of Axin in human embryonic kidney 293T cells leads to differential activation of MAPK, with robust induction for c-Jun NH2-terminal kinase/stress …

Feb 19, 2025 · Our study results demonstrate that Axin1 exacerbates HIRI by promoting the ubiquitination and degradation of PPARβ, which in turn activates the NF-κB signaling pathway. …

Axin1 has, in fact, emerged as a multidomain scaffolding protein for many other signaling pathways, including the c-Jun-NH 2-kinase (JNK) mitogen-activated protein kinase (MAPK) …

Axin is a multidomain protein that plays a critical role in Wnt signaling, serving as a scaffold for down-regulation of β-catenin. It also activates the JNK mitogen-activated protein kinase by …

Jan 30, 2024 · These encompass the WNT/β-catenin, Hippo, TGFβ, AMPK, mTOR, MAPK, and antioxidant signaling pathways. The versatile engagement of AXIN1 underscores its pivotal …

May 1, 2021 · Key points: Tamoxifen-inducible skeletal muscle-specific AXIN1 knockout (AXIN1 imKO) in mouse does not affect whole-body energy substrate metabolism. AXIN1 imKO does …