Human in vitro models for understanding mechanisms of autism …
Apr 16, 2020 · We discuss the main findings from stem cell models to date focusing on cell cycle and proliferation, cell death, cell differentiation and maturation, and neuronal signaling and …
Human pluripotent stem cell (hPSC) and organoid models of autism ...
Jun 21, 2023 · In recent years, advancements in stem cell technology have created the opportunity to model ASD in a human context through the use of pluripotent stem cells …
Getting to the Cores of Autism - Cell Press
Sep 5, 2019 · During the last decade a substantial proportion of the genetic architecture of autism spectrum disorder (ASD) has come to light. These studies have delivered a trove of …
Stem cells and modeling of autism spectrum disorders
From NSCs to mature brain cells we are able now to model the disease in a dish, filling the next pieces on the puzzle to better direct the prognostic of autism with the molecular insight along. …
Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell ...
Studies applying human induced pluripotent stem cell (iPSC)-derived organoids or spheroids to model autism spectrum disorder (ASD).
Degraded tactile coding in the Cntnap2 mouse model of autism - Cell …
We evaluate whisker touch coding in L2/3 of somatosensory cortex (S1) in Cntnap2−/− mice, which have reduced inhibition. This classically predicts excess pyramidal cell spiking, but this …
Human stem cell-based models for studying autism spectrum …
Dec 11, 2020 · Here, we provide a concise review on recent advances in the field of human iPSC-based modeling of syndromic and non-syndromic forms of ASD, with a particular focus on …
Using human pluripotent stem cell models to study autism in the …
Mar 23, 2020 · In this review, we discuss four such issues which influence the efficacy of hPSC models for studying autism, including (i) sources of variance, (ii) scale and format of study …
Mesenchymal stem cell-derived extracellular vesicles alleviate autism …
MIA offspring mice showed typical autism-like phenotypes. (A) Schematic diagram illustrating the experimental procedure of MIA offspring mice.(B-E) The inflammatory factors detection in …
Multi-omics study reveals differential expression and ... - Nature
Mar 29, 2025 · Our multi-omics study investigated the molecular mechanisms underlying autism spectrum disorder (ASD) using Shank3Δ4–22 and Cntnap2−/− mouse models. Through global …