Jan 15, 2021 · P53 is one of the most important substrates of AURKA. It has been reported that AURKA phosphorylates p53 at Ser315, after which p53 is destabilized and the G2-M transition is enhanced [ 72 ]. However, Ser106 residue phosphorylation by AURKA has the opposite effect.

Aberrant expression of the Aurora kinases–p53 protein family signaling axes appears to be critical in the abrogation of p53 protein family mediated tumor suppressor pathways frequently deregulated during oncogenic transformation process.

Specifically, Aurka regulates pluripotency through phosphorylation-mediated inhibition of p53-directed ectodermal and mesodermal gene expression. Phosphorylation of p53 not only impairs p53-induced ESC differentiation but also p53-mediated suppression of iPSC reprogramming.

Oct 24, 2024 · AURKA can modulate the activity of p53, a widely recognized tumor suppressor, by phosphorylating it on both Ser215 and Ser315 residues. 20 This phosphorylation hinders p53’s ability to transcribe genes and promotes the destruction of p53 by Mdm2. 21. Patients with a poor prognosis are typically due to metastases caused by EMT.

P53, a pro-apoptotic factor, is phosphorylated by Aurora-A at Ser 315, which facilitates MDM2-mediated ubiquitination of p53 , and at Ser 215, which inhibits transcriptional activity of p53 .

Jan 20, 2022 · Many aurora kinase A/B (AURKA/B) pathway genes are repressed in a p53-DREAM-dependent manner. We found heightened expression of RBL2 and reduced expression of AURKA/B pathway genes is...

Nov 1, 2008 · We investigated the role of Aurora kinase A (AURKA) in regulating p73-dependent apoptosis utilizing p53-deficient cancer cell lines; H1299, TE7, and HCT116p53 −/−. Overexpression of AURKA led to down-regulation of the TAp73-induced activation of the p53/p73-dependent luciferase reporter plasmid (pG13-luc).

Aug 3, 2012 · These studies showed that Aurka functions by inactivating the well-known tumor suppressor gene p53. The p53 protein acts as the "guardian of the genome" and mutations as well as deletions of...

Apr 1, 2024 · Interestingly, AurkA overexpression also interferes with p53 stabilisation and impairs its response to cellular stresses including mitotic delay or nocodazole-induced chromosomal instability.

In this study, we provide evidence showing that p53 mutation leads to elevated expression of Aurora kinase A through regulation of miR-25 and Fbxw7, thus revealing a potential molecular mechanism of p53 mutation in promoting the rapid proliferation and aggressive behavior of NE tumor cells in prostatic SCNC.