Here we show that ATG7 contributes to resistance to fungal pathogens. Genetic inactivation of ATG7 results in elevated susceptibility towards the necrotrophic fungal pathogen, Alternaria brassicicola, with atg7 mutants developing spreading necrosis

Autophagy related 7 is a protein in humans encoded by ATG7 gene. [5] [6] Related to GSA7; APG7L; APG7-LIKE. [6] ATG 7, present in both plant and animal genomes, acts as an essential protein for cell degradation and its recycling.

Dec 1, 2023 · Salt stress induces plant autophagy, which promotes the degradation and recycling of proteins, providing the macromolecules and energy needed for plant survival. Interference with ATG2 or ATG7 inhibited wheat autophagy and reduced tolerance to salt stress [99] .

Some autophagy-related subfamilies might work together on a particular biological function. For instance, the subfamilies ATG2, ATG5 and ATG7 were found to regulate leaf development and senescence and the ATG2 and ATG10 subfamilies might be responsible for plant resistance against bacteria.

Nov 21, 2024 · ATG7 acts as an E1-like activating enzyme to facilitate the conjugation between ATG8-phosphatidylethanolamine (ATG8-PE) and ATG12 during autophagosomal membrane expansion. ATG5 and ATG7 are...

FUNCTION OF ATG7 IN PLANTS. Phenotypic analyses of Atg7 mutants indicates that Atg7 disruption renders Arabidopsis (Arabidopsis thaliana) cells hypersensitive to a shortage of nutrients with features of premature leaf senescence, though the mutant is otherwise normal (Doelling et al., 2002).

Oct 2, 2023 · Many autophagy-related (ATG) proteins have been isolated with important roles in the complex autophagy process. One important group are the ATG8 proteins, which are ubiquitin-like proteins that are essential for the formation of the autophagosome lipid structures that surround the autophagic cargo.

It has been suggested that ATG7 plays an important role in plant resistance to fungal pathogens. Citation 164 WRKY33 is an essential transcription factor for plant resistance to necrotrophic pathogens in Arabidopsis.

Jan 20, 2018 · We show that Atg5 and the E1-like enzyme, Atg7, are rate-limiting components of Atg8–PE conjugation in Arabidopsis. Overexpression of ATG5 or ATG7 stimulates Atg8 lipidation, autophagosome formation, and autophagic flux.

Sep 12, 2008 · To help understand the importance of autophagy to nutrient remobilization in cereals, we describe here the ATG8/12 conjugation cascades in maize (Zea mays) and examine their dynamics during development, leaf senescence, and nitrogen and fixed-carbon starvation.