Jul 24, 2018 · In this study, we provide evidences that mtROS induce PTEN oxidation to stimulate PI3K/AKT/mTOR signaling pathway and thus promote autophagy, which is required for muscle differentiation and...

May 23, 2024 · Using genetically engineered mice with myeloid cell-specific deletion of ATG7, we observe autophagy-deficient Mφ induced systemic inflammation, impaired mitochondria, and aggravated kidney injury...

Jul 16, 2024 · During this process, mitophagy reduces the levels of mtDNA and mtROS, which inhibits the assembly of the NLRP3 inflammasome and subsequently prevents pyroptosis.

Autophagy-related protein 7 (Atg7) is required for the formation of autophagosomes. Pua et al. found that Atg7-deficient T cells had enhanced mitochondrial content, increased ROS production, and expression of pro-apoptotic proteins like Bak, cytochrome c , and AIF ( 73 ).

Lysosomal activity was required for mTOR signaling and mitochondrial oxidative metabolism. In turn, mitochondrial reactive oxygen species (mtROS), produced as a natural byproduct of oxidative phosphorylation, were necessary for keratinocyte differentiation.

During the initiation of autophagy, ATG7 acts like an E-1 enzyme for ubiquitin-like proteins (UBL) such as ATG12 and ATG8. ATG7 helps these UBL proteins in targeting their molecule by binding to them and activating their transfer to an E-2 enzyme.

We generated Atg7 ΔMye mice, which, similar to p62 ΔMye mice, exhibited enhanced IL-1β production and decreased survival after i.p. injection of LPS (Figures S7F–S7H). Thus, ATG7 also has a protective role in acute septic inflammation.

Mar 1, 2021 · Collectively, findings in this work indicated the vital part of mtROS in the CuSO 4-mediated autophagy and apoptosis. Additionally, the mtROS-induced interference with the Akt/AMPK/mTOR/ulk1 signal transduction pathway was related to the CuSO 4-mediated RAW264.7 cell apoptosis.

Meaningfully, pretreatment with the mtROS-targeted scavenger Mito-TEMPO significantly attenuated As and PSNPs co-exposure induced mitochondrial damage, ferritinophagy and ferroptosis.

Nov 25, 2024 · This review offers an overview of the current advancements in research concerning the diverse mechanisms of mitochondrial damage associated with iron overload, with a particular emphasis on mitochondrial reactive oxygen species (mtROS) as a critical component linking the various pathways of damage.