Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.

ATG5, a key component of autophagy, regulates the formation of the autophagosome, a hallmark of autophagy. ATG5 binds with ATG12 and ATG16L1 resulting in E3 like ligase complex, which is necessary for autophagosome expansion.

Mar 28, 2025 · ATG5 (Autophagy Related 5) is a Protein Coding gene. Diseases associated with ATG5 include Spinocerebellar Ataxia, Autosomal Recessive 25 and Stomatitis. Among its related pathways are Autophagy and Selective autophagy. Gene Ontology (GO) annotations related to this gene include Atg8-family ligase activity.

Oct 17, 2018 · Autophagy-related proteins (ATG) are key players in this pathway, among which ATG5 is indispensable in both canonical and non-canonical autophagy. Recent studies demonstrate that ATG5 modulates the immune system and crosstalks with apoptosis.

Oct 1, 2006 · Atg5, first discovered in yeast, is a protein involved in the early stages of autophagosome formation 2 (Fig. 1). On page 1124 of this issue, Yousefi et al. 3 report that, independent of its...

ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells. Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.

Jan 15, 2025 · We identify lysophosphatidic acid and serine as glycolytic intermediates that trigger PC death and demonstrate that the deletion of GLUT2 in ATG5-deficient mice mitigates PC neurodegeneration...

In this study, RNAi-mediated ATG5 knockdown, excluding off-target effects from consistent findings of different siRNA sequences, inhibited human disc cellular autophagy without mTOR-signaling modulation. ATG5 is essential for autophagic vesicle formation . Knockout of ATG5 results in total autophagy inhibition .

Aug 15, 2013 · Here we show that even sublethal concentrations of DNA-damaging drugs, such as etoposide and cisplatin, induce the expression of autophagy-related protein 5 (ATG5), which is both necessary...

Jul 24, 2017 · The ATG5 gene encodes a core protein involved in autophagy, a cellular process by which proteins and organelles are degraded and recycled. ATG5 plays a role in the elongation of the phagophore and its maturation into the complete autophagosome.