Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. [5] This protein is characterized as a subunit of the autophagy -related ATG12- ATG5 /ATG16 complex …

Dec 20, 2018 · Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome …

May 26, 2020 · Here, we highlight past and recent key findings on the function of ATG proteins related to autophagosome biogenesis and consider how ATG proteins control this dynamic …

Jan 4, 2024 · We discovered a neuronal role for C. elegans ATG-16.2 and its WD40 domain in lifespan, proteostasis and exopher biogenesis. Our findings suggest noncanonical functions …

Oct 17, 2022 · ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. pfam08614 …

Jun 4, 2024 · ATG16L1 truncates that lacked the C-terminal membrane binding domain catalyzed LC3B lipidation but failed to assemble coats, did not promote cup formation and inhibited the …

Oct 30, 2020 · ATG16L1 plays a crucial role during various steps leading to the conjugation of ATG8 proteins and accumulating recent data have revealed multifaceted activities of this …

The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review …

Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Present with 573 molecules/cell in log phase SD medium. …

Mar 1, 2023 · Here, we find that ATG16L1 has two distinct binding sites for interacting with WIPI2b, the previously reported WIPI2b-binding site (WBS1) and the previously unidentified …