ATG12 - Wikipedia
ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998). [supplied by OMIM] [6] Autophagy requires the covalent attachment of the protein Atg12 to …
ATG12 Gene - GeneCards | ATG12 Protein | ATG12 Antibody
Mar 28, 2025 · ATG12 (Autophagy Related 12) is a Protein Coding gene. Diseases associated with ATG12 include Stomatitis and Mouth Disease. Among its related pathways are Autophagy …
ATG12 deficiency leads to tumor cell oncosis owing to diminished ...
Dec 16, 2019 · ATG12, which we observed in normal cells to be partially localized in mitochondria, is upregulated in multiple types of solid tumors in comparison with normal …
The Atg8 and Atg12 ubiquitin-like conjugation systems in …
Among the approximately 30 autophagy-related (Atg) genes identified so far, there are two ubiquitin-like proteins, Atg12 and Atg8. Analogous to ubiquitination, Atg12 is conjugated to …
The ATG conjugation systems in autophagy - ScienceDirect
Apr 1, 2020 · Autophagosome formation and maturation involve the two ubiquitin-like systems: The ATG8 and ATG12 systems. ATG8 (LC3s and gamma-aminobutyric acid …
ATG12 deficiency results in intracellular glutamine depletion ...
We observed decreased intracellular L-glutamine levels in ATG12-deficient cells during hypoxia and increased cell killing after L-glutamine depletion, indicating a central role for ATG12 in …
Emerging roles of ATG proteins and membrane lipids in ... - Nature
May 26, 2020 · Recently, there is accumulating evidence showing that some ATG proteins have the ability to directly interact with membranes, transfer lipids between membranes and …
Autophagy-related gene 12 (ATG12) is a novel determinant of
ATG12 silencing significantly reduced JIMT1 tumor growth induced by subcutaneous injection in nude mice. Remarkably, the outgrowth of trastuzumab-unresponsive tumors was prevented …
9140 - Gene ResultATG12 autophagy related 12 [ (human)]
ATG12 is a novel determinant of breast cancer primary resistance to HER1/2-targeted therapeutics. These data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after …
Structure of the Atg12–Atg5 conjugate reveals a platform for ...
Atg12 is conjugated to Atg5 through enzymatic reactions similar to ubiquitination. The Atg12–Atg5 conjugate functions as an E3-like enzyme to promote lipidation of Atg8, whereas lipidated Atg8 …