The augmented effect of CGP (0.1μM) on high stretch-induced ANP secretion was attenuated by the pretreatment with AT2R antagonist or inhibitor for phosphoinositol 3-kinase (PI3K), nitric …

Nov 7, 2002 · For example, Ang II reduces sGC activity/expression, induces cGMP hydrolyzing PDE expression, and reduces PKG activity. Ang II, via the AT2 receptor, results in a kinin …

Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models …

AT2 receptors contribute to acute blood pressure-lowering and vasodilator effects of AT1 receptor antagonism in conscious normotensive but not hypertensive rats.

Sep 1, 2013 · In this study, to define the signaling pathway of AT 2 R agonist-induced ANP secretion, atria were pretreated with an inhibitor for PI3K, NOS, sGC, or PKG. Pretreatment …

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′, 5′-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

Sep 1, 2013 · Activation of AT2 receptors or AT1 receptor blockade prevents the development of myocardial hypertrophy in ZDF rats through the modulation of the miR-30a-3p/PTEN interaction.

Mar 4, 1997 · The present study investigated the level of gene expression at the mRNA level for the AT1a and AT2 receptor subtype genes in failing and nonfailing human ventricular …

Jun 18, 2013 · Angiotensin II (Ang II) type 1 receptor (AT1R) mediates the major cardiovascular effects of Ang II. However, the effects mediated via AT2R are still controversial. The aim of the …

Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class medication was riociguat, …