Mar 1, 2023 · Precision cut lung slices (PCLS) have gained increasing interest in asthma research. To generate PCLS, the lung from donors is usually instilled with warm liquid agarose via tracheal, and then immersed in the ice-cold buffer to solidify the agarose.

Dec 21, 2015 · A multi-component microfluidic small airway-on-a-chip model provides new opportunities to study human lung inflammatory disorders such as chronic obstructive pulmonary disease (COPD) and asthma, and to test preclinical drug candidates outside the human body.

Dec 21, 2015 · Here we describe the development of a human lung 'small airway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular endothelium that...

Here, we describe a new human-relevant model of rhinovirus-induced asthma exacerbation that recapitulates viral infection of asthmatic airway epithelium and neutrophil transepithelial migration, and enables evaluation of immunomodulatory therapy.

Airway remodeling, as a predominant characteristic of asthma, refers to the structural changes that occurred both in the large and small airways. These pathological changes not only contribute to airway hyperresponsiveness and airway obstruction, but also predict poor outcomes of patients.

Leverage our expertise with a wide array of well-characterized in vivo models, a variety of administration routes (including inhalation), and clinically relevant endpoints to tailor your respiratory discovery projects.

In the present study, we established eosinophilic asthma through traditional OVA immunization and, on this basis, established neutrophilic asthma and mixed-granulocytic asthma by intratracheal administration of different doses of lipopolysaccharide (LPS).

Asthma is characterized by chronic lower airway inflammation that results in airway remodeling, which can lead to a permanent decrease in lung function. The pathophysiology driving the development of asthma is complex and heterogenous.

Nov 28, 2014 · Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway obstruction and airflow limitation and pose a huge burden to society. These obstructive lung diseases impact the lung physiology across multiple biological scales.

Asthma Model. Biocytogen offers robust and validated asthma models induced through various methods. Notably, we have developed a series of target-humanized mice, including B-hTSLP/hTSLPR and B-hIL4/hIL4RA mice, to facilitate the evaluation of asthma therapies.