Arginase (EC 3.5.3.1, arginine amidinase, canavanase, L-arginase, arginine transamidinase) is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H 2 O → ornithine + urea. It is the final enzyme of the urea cycle. It is ubiquitous to all domains of life.

This introductory section will outline the role played by the ureohydrolase enzyme arginase in health and disease, emphasizing the involvement of arginase in disease and injury conditions that affect the cardiovascular system, the kidneys, neoplastic malignancies, and the brain and retina.

Arginase: from urea cycle enzyme to immune cell component. The enzyme arginase hydrolyzes L-arginine to the products L-ornithine and urea. In mammals, two arginase isoenzymes (designated arginase I and II) exist.

Arginase is the enzyme that converts L-arginine to urea and L-ornithine, functions important for protection against NH 3 toxicity and cell growth and repair. Excessive arginase activity has been linked to cardiovascular diseases due to actions in reducing the supply of L-arginine needed by nitric oxide (NO) synthase to produce NO

Apr 1, 2018 · Here, we review the involvement of arginase in diseases affecting the cardiovascular, renal, and central nervous system and cancer and discuss the value of therapies targeting the elevated activity of arginase.

Arginase is a manganese-containing enzyme that catalyzes the breakdown of l-arginine into urea and l-ornithine. It plays a crucial role in the urea cycle and is found in various tissues in the body, with different isozymes serving specific functions. AI generated definition based on: Toxicological Survey of African Medicinal Plants, 2014

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former provides protection against NH3; the latter serves to stimulate cell growth and other physiological functions.

phasizing the involvement of arginase in disease and injury conditions that affect the cardiovascular system, the kid-neys, neoplastic malignancies, and the brain and retina. Increases in arginase expression and activity have been re-ported in many diseases and syndromes. The activity of arginase was initially associated with liver function and

Arginase regulating various cellular functions and processes (senescence, apoptosis, proliferation, inflammation, and autophagy) plays key roles in the pathogenesis of cardiovascular diseases, such as hypertension, atherosclerosis, stroke, …

Apr 27, 2015 · Arginase (bottom, left) is the final enzyme in the urea cycle within the liver, which restarts the cycle through the synthesis of L-citrulline from carbamoyl-phosphate (1) and L-ornithine (2) by OTC (center). It should be noted that that …