The current study explores this simple observation, which is based on sequence properties. If Lys is favored over Arg for proteins that have evolved to function at higher concentration, it might be expected that protein (or mRNA) levels show a correlation with Lys to Arg ratio.

Dec 1, 2022 · Most strikingly, ATP shares a common mechanism with nucleic acids in binding Arg/Lys residues of IDRs, thus emerging as a general mediator for interactions between IDRs and nucleic acids.

Lys-Arg is a dipeptide formed from L-lysine and L-arginine residues. It has a role as a metabolite. L-lysyl-l-arginine is under investigation in clinical trial NCT03972488 (Study to Evaluate the …

The differences in the chemical nature of the side chain groups for Arg (guanidinium) and Lys (amino) confer distinct properties to the peptides, affecting their antimicrobial activity. In most cases the presence of Lys has been associated with …

Oct 10, 2013 · The basic amino acids lysine (Lys) and arginine (Arg) play important roles in membrane protein activity, the sensing of membrane voltages, and the actions of antimicrobial, toxin, and cell-penetrating peptides.

Sep 20, 2024 · Herein, we demonstrate a chemoselectivity shift in the MGO reaction, from two lysines to between one Lys and one Arg in the presence of TFE, producing Arg-Lys imidazole cross-link.

Jan 31, 2024 · Herein, we develop a pair of complementary photo-arginine/ δ-photo-lysine (R-dz/K-dz) tools to explore the interactomes of Arg and Lys hPTMs. We discover that H3R2 asymmetric methylation (H3R2me2a) can recruit MSH6 and repel DPF2/ RBBP4/RBBP7 at the peptide, nucleosome and chromatin level.

The study not only unveils the first residue-resolution mechanism of the nucleic-acid-driven LLPS of TDP-43 PLD, but also decodes a general principle that not just TDP-43 PLD, all Arg/Lys-containing IDRs are cryptic nucleic-acid-binding domains that …

In this review, evidence for secretory vesicle cathepsin L and Arg/Lys aminopeptidase as a distinct proteolytic pathway for processing the prohormone proenkephalin is presented.

Lys-Arg-Lys | C18H38N8O4 | CID 448139 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.