Studies have shown that macrophages produce a high level of AREG in lipopolysaccharide-induced acute lung injury, activate the EGFR-AKT pathway, inhibit inflammatory cell infiltration and inflammatory factor expression, and have a protective effect on lung tissue.

Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injury and repair. We sought to determine whether Areg expression increases in CLAD, localize the cellular source of Areg induction in CLAD, and assess its …

Jul 27, 2021 · IPF epithelia treated with Verteporfin or AG1478 had reduced YAP target gene expression AREG (f) and CTGF (g) as well as ERBB family receptor ERBB2 (h) and EGFR (i) 48 h after treatment, nearly...

Mar 6, 2023 · Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza virus infection through production of the EGFR ligand amphiregulin (Areg); however, how Treg cells engage with progenitors within the alveolar niche is unknown.

Sep 5, 2024 · We showed that amphiregulin (AREG) expression is significantly elevated in intermediate alveolar stem cells of mouse fibrotic lungs and IPF patients. High levels of serum AREG correlate significantly with profound deteriorations in lung function in IPF patients.

Overview of the in vitro, in vivo and clinical findings for the role of the ErbB/ligand system in lung fibrosis.

Dec 28, 2022 · These results suggested that AREG mediates the TGF-β-induced EMT in human lung epithelial cells through EGFR/JNK/AP-1 activation. Understanding the role of AREG in the EMT could foster the development of therapeutic strategies for airway remodeling in …

Aug 23, 2023 · Whole tumor single-cell RNA sequencing (scRNA-seq) analysis and blockade experiments revealed that the amphiregulin (AREG)–epidermal growth factor receptor (EGFR) axis mediated cross-talk between IL1RL1 + T reg cells and CAFs.

Jan 1, 2020 · Amphiregulin (AREG) can promote the lung repair process but can also lead to fibrotic remodeling. The objective of this study was to determine the role of AREG in altering recovery from environmental dust exposure in a murine in vivo model and in vitro using cultured human and murine lung fibroblasts.

Jul 14, 2021 · Our study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to...