May 14, 2013 · Apolipoprotein E (apoE) is a small apolipoprotein synthesized mostly by the liver that serves as a ligand to the low‐density lipoprotein (LDL) receptor (LDLR) and the LDL‐receptor–related protein‐1 (LRP1) and plays an essential role in metabolism by promoting cellular uptake of lipoproteins. 1, 2 Even though most plasma apoE is borne in ...

ApoE mediates the interaction of apoE-containing lipoproteins and lipid complexes to the LDL receptor, the LDL receptor-related protein (LRP), the VLDL receptor, the apoE receptor-2, and gp330. The apoE isoforms differ in their ability to interact with these receptors.

Apolipoprotein E (apoE) is a potent modulator of plasma lipoprotein and cholesterol levels whose mode of action is mediated by interaction with members of the low-density lipoprotein (LDL) receptor family. Transgenic mice over-expressing apoE have decreased plasma cholesterol and are resistant to diet-induced atherosclerosis [1].

Apo-E interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing (catabolism) of triglyceride -rich lipoproteins. [7] . In peripheral tissues, Apo-E is primarily produced by the liver and macrophages, and mediates cholesterol metabolism.

ApoE2 and apoE4 increase the risk for heart disease: apoE2 increases atherogenic lipoprotein levels (it binds poorly to LDL receptors), and apoE4 increases LDL levels (it binds preferentially to triglyceride-rich, very low density lipoproteins, leading to downregulation of LDL receptors).

Sep 2, 2022 · APOE2 genes are generally associated with low LDL levels. On the other hand, the E4 variant is characterized by faster cholesterol metabolism.

Sep 29, 2023 · One genetic adaptation to protect against pathogens comes from the hunter-gatherer APOE-e4 allele and elevated LDL. The APOE-e4 allele has consistently been associated with higher levels of total cholesterol, LDL, and oxidized …

The low-density lipoprotein receptor (LDLR) has a high affinity for apoE, and is the only member of its receptor family to demonstrate an apoE isoform specific binding affinity (E4>E3>>E2). Evidence suggests that a functional interaction between apoE and …

Nov 11, 2024 · Here, we report that impaired low-density lipoprotein (LDL) receptor (LDLR) binding of lipidated ApoE2 (lipApoE2) avoids LDLR recycling defects observed with lipApoE3/E4 and decreases the uptake of cholesteryl esters (CEs), which are lipids linked to neurodegeneration.

Apr 13, 2023 · The APOE variants p.(Arg154Ser), p.(Arg163Cys), and p.(Arg165Trp), located in the APOE receptor-binding site for the LDLr, are mostly present in subjects with CHLP. Their phenotype includes high VLDLc, high VLDLc/apoB ratio, DBL criteria, and reduced VLDL affinity for the LDL receptor.