Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. [5] [6] As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism.

Apolipoprotein A1 (ApoA1) is the primary protein associated with high-density lipoprotein (HDL) particles, and plays a central role in reverse cholesterol transport. HDL cholesterol (HDL-C) and ApoA1 concentrations are inversely related to the risk for coronary artery disease (CAD).

Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation.

Feb 16, 2021 · Purpose of the review: Apolipoprotein (APO) A1, the main apolipoprotein of plasma high-density lipoproteins (HDLs), has several well documented cardioprotective functions. A number of additional potentially beneficial functions of APOA1 have recently been identified.

Mar 28, 2025 · APOA1 (Apolipoprotein A1) is a Protein Coding gene. Diseases associated with APOA1 include Hypoalphalipoproteinemia, Primary, 2 and Amyloidosis, Hereditary Systemic 3. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Response to elevated platelet cytosolic Ca2+.

The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). Learn about this gene and related health conditions.

Jan 11, 2025 · This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma.

Oct 1, 2022 · Apolipoprotein A1 (ApoA1) is a member of the Apolipoprotein family of proteins. It's a vital protein that helps in the production of high-density lipoprotein (HDL) particles, which are crucial for reverse cholesterol transport (RCT). It also has anti-inflammatory, anti-atherogenic, anti-apoptotic, and anti-thrombotic properties.

Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin (PubMed:1909888). Interacts with NDRG1 (PubMed: 15922294 ).

Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed.