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Among them, atypical protein kinase C (aPKC) is likely the most studied kinase in cell polarity and has the largest number of downstream substrates characterized so far. More than half of the polarity proteins that are essential for regulating cell polarity have been identified as …

Jun 25, 2018 · More than half of the polarity proteins that are essential for regulating cell polarity have been identified as aPKC substrates. This review covers mainly studies of aPKC in regulating anterior-posterior polarity in the worm one-cell embryo and apical-basal polarity in epithelial cells and asymmetrically dividing cells (for example, Drosophila ...

Atypical Protein Kinase Cs (aPKCs) are a group of protein kinases with an evolutionarily conserved role in regulating cell polarity—a feature central to essentially all aspects of neuronal biology.

The protein kinase C (PKC) family: PKC family is a subgroup of the AGC serine-threonine kinases that consists of 10 distinct members in mammals (Spitaler and Cantrell, 2004). They all contain a C-terminal catalytic domain that is connected to the N-terminal regulatory domains.

Dec 17, 2018 · Our study reveals that aPKC controls physiological and pathological vascular growth by regulating the transcriptional activity and abundance of key transcription factors FoxO1 and c-Myc....

Aug 8, 2009 · Our findings show that overexpression of a constitutively active membrane-targeted aPKC (aPKC-CAAX) suppresses primary neurogenesis in deep cells, enhances superficial gene expression and promotes cell proliferation.

Jun 25, 2018 · Among them, atypical protein kinase C (aPKC) is likely the most studied kinase in cell polarity and has the largest number of downstream substrates characterized so far. More than half of the polarity proteins that are essential for regulating cell polarity have been identified as aPKC substrates.

Apr 10, 2016 · atypical Protein Kinase C (aPKC) regulates stem cell fate decision using multiple mechanisms. aPKC polarizes fate determinant proteins during asymmetric cell division. aPKC shortens the cell cycle to promote cell proliferation. aPKC phosphorylates conserved transcription factors to regulate cell fate decisions.

Feb 19, 2025 · Results identify the Cdc42/Par6/atypical protein kinase C (aPKC) Par polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia. Data show that Zif is a transcription factor that directly represses aPKC transcription [Zif].