Nov 6, 2024 · Open the resulting .gff file in the latest ApE. Alternatively, you can export a genomic region (from the genome viewer) as a FASTA formatted file (using the menu on the upper left). You can add the feature tracks by downloading the GFF3 feature track files using the same menu.

Apr 7, 2018 · TME is a crucial component of an APE. The difference is that the distal part should be covered by the levator muscles and incorporate the anal sphincters – a “TME with a levator wrap and added anus”.

With the new concept of APE, based on well-defined anatomical structures, the procedure can be categorized as intersphincteric APE, extralevator APE, and ischioanal APE. This article discusses the technical aspects and results from this approach.

Abdominoperineal excision (APE) procedure is still the main approach to low rectal cancer patients with short distance from the anal verge, obvious invasion of adjacent organs and narrow pelvis. Although the principle of TME (total mesorectal excision) needs to be obeyed in the abdominal phase of AP …

May 21, 2011 · After introduction of total mesorectal excision (TME) as the gold standard for rectal cancer surgery, oncologic results appeared to be inferior for abdominoperineal excision (APE) as compared to anterior resection.

Nagtegaal and colleagues assessed 846 AR specimens and 373 APE specimens from the Dutch TME trial and found that the plane of resection was within the sphincter muscle, the submucosa, or lumen in more than one-third of the APE cases, and in …

Jun 22, 2022 · Extralevator (ELAPE) and abdominoperineal excision (APE) are two major surgical approaches for low rectal cancer patients. Although excellent short-term efficacy is achieved in patients undergoing ELAPE, the long-term benefits have not been established.

ApE is a freely available program written over the last 17 years by a molecular biologist for molecular biologists. Thus, it leverages the insider knowledge of what makes a successful DNA editing program.

Apr 9, 2025 · Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future ...

Feb 4, 2022 · A plasmid Editor (ApE) is a free, multi-platform application for visualizing, designing, and presenting biologically relevant DNA sequences.