Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin …

The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle. The APC/C and ...

Jul 20, 2014 · The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins to control various events during...

We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a …

Here, we discuss the most recent developments in the APC/C field concerning structure, substrate recognition, and catalysis. Keywords: Ubiquitination, anaphase-promoting complex, spindle assembly checkpoint, mitosis, cyclosome, phosphorylation, electron microscopy.

Jun 15, 2015 · The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit.

Jun 2, 2011 · The APC/C (anaphase-promoting complex, also known as the cyclosome) is an E3 ubiquitin ligase that ensures temporal order of the cell cycle by degrading different cell cycle regulators at...

Apr 15, 2019 · APC/C influences cell differentiation by exerting at least three types of context-dependent mechanism: (i) regulating the expression levels of cell type-specific transcriptional regulators; (ii) modulating cellular responses to signalling pathways; and (iii) regulating the organisation and functions of centrosomes.

Jul 13, 2016 · This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics.

May 23, 2019 · The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle.