Feb 19, 2020 · To prevent aberrant transcriptional activation in the absence of Wnt, a cytoplasmic β-catenin destruction complex composed of APC, Axin, CK1-α, and GSK-3β maintains low levels of β-catenin...

AXIN1-truncating mutations at least partially affect β-catenin regulation, whereas this is only the case for a subset of missense mutations. Consistently, most colorectal and liver cancers carrying missense variants acquire mutations in other β-catenin regulatory genes …

Jan 30, 2024 · Furthermore, we have introduced the innovative concept of the AXIN1-Associated Phosphokinase Complex (AAPC), where the scaffold protein AXIN1 assumes a pivotal role in orchestrating site-specific phosphorylation modifications through interactions with various phosphokinases and their respective substrates.

Adenomatous polyposis coli (APC) and Axin interactions serve an important role in colorectal cancer (CRC) pathogenesis. The aim of the present study was to assess the combined effects of Axin and APC co-expression in CRC cells, and to determine the underlying mechanisms involved.

Sep 22, 2015 · APC, a key negative regulator of Wnt signaling in development and oncogenesis, acts in the destruction complex with the scaffold Axin and the kinases GSK3 and CK1 to target βcatenin for destruction. Despite 20 years of research, APC's …

Aug 19, 2021 · We reveal that AXIN1 polymerization and APC promote β-catenin capture, phosphorylation, and ubiquitylation. APC facilitates β-catenin's flux through the complex by limiting ubiquitylation processivity and directly interacts with the SCF β-TrCP E3 ligase complex in a β-TrCP-dependent manner.

Mar 30, 2025 · AXIN1 (Axin 1) is a Protein Coding gene. Diseases associated with AXIN1 include Caudal Duplication Anomaly and Craniometadiaphyseal Osteosclerosis With Hip Dysplasia. Among its related pathways are CTNNB1 S33 mutants aren't phosphorylated and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

Aug 4, 2021 · We reveal that AXIN1 polymerization and APC promote β-catenin capture, phosphorylation, and ubiquitylation. APC facilitates β-catenin’s flux through the complex by limiting ubiquitylation processivity and directly interacts with the SCF β-TrCP E3 ligase complex in a β-TrCP-dependent manner.

HCCs frequently display activated Wnt signaling, but often lack mutations in CTNNB1 or APC; hence, the AXIN1 gene was screened for mutations. Out of 100 primary HCCs studied, six AXIN1 alterations were found in five tumors, including three deletions and three premature stop codons.

Aug 31, 2017 · Axis inhibition protein 1 (Axin1) tumor suppressor is another scaffold protein in the b-catenin destruction complex, but endogenous Axin1 proteins are tightly controlled by tankyrase-dependent degradation in colorectal cancer cells.