Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1]

The dimeric transcription factor complex Activator Protein-1 (AP-1) is a group of proteins involved in a wide array of cell processes and a critical regulator of nuclear gene expression during T-cell activation. It is also one of the downstream targets of the MAPK signaling cascade.

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site.

AP-1 is another redox-sensitive transcription factor, which regulates cellular proliferation and differentiation during the neoplastic transformation [52]. AP-1 is composed of dimers between the Fos (c-Fos, FosB, Fra-1, and Fra-2) and the Jun (c-Jun, JunB, and JunD) family members.

AP-1 proteins are primarily considered to be oncogenic, but recent studies have challenged this view — some AP-1 proteins, such as JUNB and c-FOS, have been shown to have tumour-suppressor...

AP-1 proteins are a versatile family of dimeric transcription factors. The activator protein-1 (AP-1) proteins are a collection of transcription factors characterized by the presence of a basic leucine zipper (bZip) domain (Fig. 1a).

May 1, 2002 · AP-1 proteins as regulators of cell death and survival. Apoptosis suppresses oncogenic transformation, and controls organogenesis and immune responses.

Nuclear factor κB (NF-κB) and activator protein 1 (AP-1) transcription factors regulate many important biological and pathological processes. Activation of NF-κB is regulated by the inducible phosphorylation of NF-κB inhibitor IκB by IκB kinase. In ...

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified.

AP-1 has been implicated in regulating various physiological and pathological cellular processes including proliferation, differentiation, growth, apoptosis, cell migration, and transformation . AP-1 inhibitors have therefore emerged as an attractive drug class for cancer therapy.