Feb 5, 2022 · The cellular AOX system consists of a series of components including enzymatic and non-enzymatic species, mainly superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) as enzymatic species and glutathione which is a non-enzymatic AOX.

The mode of actions of antioxidants for maintaining cellular homeostasis in vivo are directly linked to their action as free radical scavenger to neutralize free radicals or by boosting the antioxidant system, including enzymatic antioxidants such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), and nonenzymatic ...

Feb 1, 2016 · After exposure to oxidative stress, pYES2At AOX 1a showed better survival and a decrease in reactive oxygen species (ROS) when compared to S. cerevisiae with empty vector (pYES2). Furthermore, pYES2At AOX 1a sustained growth by regulating GPX2 and/or TSA2, and cellular NAD + / NADH ratio.

Sep 1, 2002 · In contrast to CAT (d), APX and GPX require an ascorbate (AsA) and/or a glutathione (GSH) regenerating cycle (a–c). This cycle uses electrons directly from the photosynthetic apparatus (a) or NAD(P)H (b,c) as reducing power.

Improving GPx activity through targeting lipid peroxides with appropriate AOX supplementation should be explored in vivo to protect the vascular endothelium directly from oxidative stress during neovascularization.

Aug 18, 2022 · Plants have different systems that act to regulate ROS formation by using alternative oxidase (AOX), uncoupling protein (UCP) and plastid terminal oxidase (PTOX) or ROS scavenging by enzymatic and non-enzymatic antioxidants.

Aug 7, 2008 · Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidative stress.

... there was a decrease in GPx activity between day 21 and day 42 for all dietary groups under TN conditions, nevertheless supplemental BET and AOX increased GPx over that of the controls.

Jun 24, 2021 · In this study, the effect of inhibition of AOX with different concentrations of salicylhydroxamic acid (SHAM) on the tobacco root development was investigated. We show here that AOX inhibition significantly impaired the development …

Apr 25, 2023 · Based on the known complexity of reactive oxygen species (ROS) functions in both the physiology and pathophysiology of glucose homeostasis, it is suggested that inappropriate dosing leads to the failure of AOXs in T2D treatment.