May 25, 2023 · Interleukin-18 (IL-18) is an effective pro-inflammatory cytokine for the host defense against infections and controls the innate and acquired immune response. Both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes, and mesenchymal cells produce IL-18.

Aug 18, 2020 · In a new study in Nature, Zhou et al. identify IL-18BP as a novel soluble immune checkpoint, and describe engineering of a decoy-resistant IL-18 to overcome this barrier and drive potent...

IL-18 is a proinflammatory cytokine that facilitates type 1 responses. Together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS).

Our IL-18 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse, Goat and Sheep. These antibodies have been verified by Relative expression and Neutralization to confirm specificity to IL-18. Find the IL-18 antibody that fits your needs.

Jun 24, 2020 · Here we show that IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.

IL-18, a member of the IL-1 family, is similar to IL-1β for being processed by caspase 1 to an 18 kDa-biologically active mature form. IL-18 binds to its specific receptor (IL-18Rα, also known as IL-1R7) forming a low affinity ligand chain.

Blocking IL-18 using anti-IL-18 antibodies or the CD40–CD40L interaction effectively reduced disease severity, even in acute and chronic stages. This effect was attributed to up-regulated TGF-β and CTLA-4 and down-regulation of Th1 cytokines and CD40L [88, 109].

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell.

The IL-18BP has been used safely in humans and clinical trials of IL-18BP as well as neutralizing anti-IL-18 antibodies are in clinical trials. This review updates the biology of IL-18 as well as its role in human disease.

Mar 1, 2016 · Circulating levels of interleukin (IL)-18 appear to be associated with a number of micro- and macrovascular comorbidities of obesity and T2DM. This study was designed to investigate whether inhibition of IL-18 had any therapeutic benefit in the treatment of T2DM.