Apr 27, 2022 · ANLN promotes PLK1-mediated RACGAP1 phosphorylation and RhoA activation to ensure cytokinesis fidelity. To explore the function of ANLN in HCC tumorigenesis, we …

The transfection of siCDK1 in SK-Hep1 resulted in a disordered cell cycle. Furthermore, CDK1 knockdown suppressed the expression of PLK1, ANLN, and SGOL2. The CDK1 …

A total of 5 genes in ‘PLK1 signaling events,’ namely AURKA, polo-like kinase 1 (PLK1), cell division cycle 25C (CDC25C), budding uninhibited by benzimidazoles (BUB1), and targeting …

Aug 5, 2022 · We found that high ANLN expression was associated with the clinical benefits of ICB therapy (PD-1) in patients with bladder cancer and glioblastoma, while low ANLN …

ANLN promotes PLK1-mediated RACGAP1 phosphorylation and RhoA activation to ensure cytokinesis fidelity. To explore the function of ANLN in HCC tumorigenesis, we …

The results from quantitative real-time RT-PCR showed the significantly decreased expression levels of PLK1, ANLN, and SGOL2 following CDK1 knockdown and CDK1 knockdown …

Furthermore, CDK1 knockdown sup-pressed the expression of PLK1, ANLN, and SGOL2. The CDK1-PLK1/SGOL2/ANLN pathway med-iating abnormal cell division in the cell cycle might …

Mechanistically, ANLN acts as a scaffold to strengthen interaction between RACGAP1 and PLK1. ANLN promotes PLK1-mediated RACGAP1 phosphorylation and RhoA activation to ensure …

Apr 10, 2020 · Apart from higher expression of CDK1 and other core genes in HCC, knockdown of CDK1 led to suppression of SGOL2, ANLN, and PLK1, showing a pathway termed as CDK1 …

Apr 1, 2016 · PLK-1 is a key player in the eukaryotic cell cycle. Cell cycle progression is precisely controlled by cell cycle regulatory kinases. PLK-1 is a mitotic kinase that actively regulates the …