In archaeogenetics, the term Ancient North Eurasian (ANE) refers to an ancestral component that represents the lineage of the people of the Mal'ta–Buret' culture (c. 24,000 BP) and populations closely related to them, such as the Upper Paleolithic individuals from Afontova Gora in Siberia.

Acute necrotizing encephalopathy (ANE) or sometimes necrotizing encephalitis or infection-induced acute encephalopathy (IIAE) is a rare type of brain disease (encephalopathy) that occurs following a viral infection. [4] Most commonly, it develops secondary to infection with influenza A, influenza B, and the human herpes virus 6. ANE can be ...

Although the exact cause of ANE hasn’t been fully determined, doctors do know that it’s usually triggered by a viral infection. People with changes in the RANBP2 gene may be more likely to develop ANE because this gene helps move materials in and out of cells. When altered, the protein it makes doesn’t work correctly, making it harder for brain cells to …

Acute Necrotizing Encephalopathy, as described by the Genetic & Rare diseases Information Center (USA) is a rare disease characterized by brain damage (encephalopathy) that usually follows an acute febrile disease, mostly viral infections.

Genetic (also known as familial) acute necrotizing encephalopathy (ANE1) is a rare disease presenting with encephalopathy often following preceding viral febrile illness in patients with a genetic predisposition resulting from a missense mutation in the gene encoding RAN Binding Protein 2 (RANBP2).

Acute necrotizing encephalopathy (ANE) is a devastating neurologic condition that can arise following a variety of systemic infections, including influenza and SARS-CoV-2. Affected individuals typically present with rapid changes in consciousness, focal …

The term “acute necrotizing encephalopathy” (ANE) continues to be used for ANE that is sporadic (i.e., a single occurrence in a family of unknown cause). Infection-induced acute encephalopathy 3 (IIAE3) is reserved for ANE with a documented RANBP2 pathogenic variant.

Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration.

However, in some children recurrent episodes of ANE occur due to an inherited genetic predisposition. The most common gene attributed to inherit ANE is called RANBP2, a gene involved in energy metabolism in brain cells.

ANE is a type of necrotizing lesion of the brain parenchyma. There are two major types of reported cases. One is isolated and sporadic ANE, which is primarily caused by viral infections, particularly influenza and HHV-6 virus.