Sep 22, 2017 · The patient underwent wide local excision with central arch resection of mandible with bilateral modified neck dissection and pectoralis major myocutaneous flap for reconstruction followed by postoperative radiotherapy. During the follow up, patient developed severe “Andy Gump deformity” [Figure 1].

Jul 12, 2022 · What are the benefits of subcutaneous drug formulations? How does daratumumab improve multiple myeloma treatment outcomes? Closing out their discussion on a clinical scenario of metastatic HSPC,...

The Heat Safety & Performance Coalition (HSPC) provides heat-safety research, education, and awareness and was created to help organizations develop and implement heat safety solutions to keep workers safe.

In the past 5 years, several systemic therapies have been introduced for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). While androgen deprivation therapy (ADT) remains the mainstay of treatment of mHSPC, docetaxel chemotherapy and oral anti-androgens have demonstrated survival benefit when added to ADT.

We identified a core transcriptional regulatory network (TRN) in HSPC-like blasts that is combinatorically controlled by HOXA/AP1/CEBPA. This TRN signature can predict chemotherapy response and long-term clinical outcomes.

Sep 1, 2021 · Androgen deprivation therapy remains the backbone therapy for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC).

Oct 19, 2020 · Here, we review evidence of signals emerging from HSPCs through secreted autocrine or paracrine factors, including extracellular vesicles, and via direct contact within the niche. We also discuss...

We propose gene transfer to hematopoietic stem/progenitor cells (HSPC) as a novel approach to deliver the CD19-specific CAR, with potential for ensuring persistent production of effector cells of multiple lineages targeting B-lineage malignant cells.

Mar 15, 2024 · Formulate personalized treatment plans for patients with HSPC, considering patient-specific factors, up-to-date best-practice treatment strategies, recent clinical trial findings, and expert recommendations