ANARCI is a tool for numbering amino-acid sequences of antibody and T-cell receptor variable domains. Use the form below to identify domains and annotate them with either the IMGT, Chothia, Kabat, Martin (Enhanced Chothia) or AHo numbering scheme.

Chothia - is defined for heavy and light chain antibody chains only (in ANARCI). Numbering in the two chain types are not equivalent. Insertions occur at specific positions and can occur in both the framework and the CDRs.

Sep 30, 2015 · We have developed ANARCI, a program for annotating antigen receptor variable domain amino-acid sequences with five commonly used numbering schemes. The program can be run as command-line tool or imported as a Python module for incorporation in custom scripts.

ANARCI performs alignments of sequences to databases of Hidden Markov Models (HMMs). Those that align with a significant score are classified by species and chain type. They are then numbered with a scheme of the user's choosing.

ANARCI gives the insertion codes as letters. Insertions at CDR3 are placed symmetrically about imgt positions 111 and 112. e.g. 111-ABCD DCBA-112. Kabat: is defined for heavy and light chain antibody chains only (in ANARCI).

# ANARCI - Antibody Numbering and Antigen Receptor ClassIfication # Copyright (C) 2016 Oxford Protein Informatics Group (OPIG) # This program is free software: you can redistribute …

Motivation: Antibody amino-acid sequences can be numbered to identify equivalent positions. Such annotations are valuable for antibody sequence comparison, protein structure modelling and engineering.

Jan 15, 2016 · Results: ANARCI is a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo.

ANARCI is a tool that can classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo.

Convenience Python APIs for antibody numbering and alignment using ANARCI. Try it out in your browser using Binder: See AbNumber Documentation for the full reference. Install using Bioconda: Note: Windows is not supported due to HMMER dependency. AbNumber is currently only available on UNIX & MacOS.