Sep 2, 2022 · An antinuclear antibody test can help your doctor diagnose an autoimmune disease such as lupus. Find out how this blood test is done and what your results might mean.

Nuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding of monoclonal nuclear ...

Antinuclear Antibodies (ANA) An ANA is an antibody against At Clinipath Pathology, the test is performed by immunoflu titre is given, as well as the pattern of the fluorescence. The ANA may represent many autoantibodies, so once an ANA is found, often further testing needs to be done to elucidate the type of antibody.

May 19, 2022 · Raynaud's phenomenon persisted associated with acrocyanosis, white nails, and positive ANA (1:1280 in a nucleolar pattern). POEMS syndrome was suspected, and serum protein electrophoresis (SPEP) was done.

Sep 30, 2021 · We identified a new unique pattern of nuclear stain by immunofluorescence in kidney biopsies that suggests the presence of monoclonal ANA. Workup for underlying monoclonal gammopathy is warranted in such patients.

Apr 4, 2024 · This topic will review the clinical utility and limitations of ANA testing, techniques for detecting ANAs, and interpretation of ANA testing, including significance of staining patterns and associated autoantibodies.

Nov 16, 2024 · The ANA test is a sensitive screening test used to detect autoimmune diseases. Learn how the ANA test procedure is performed and the interpretation of results determined.

People with multiple myeloma typically have abnormally high levels of either kappa or lambda light chain, and an abnormal ratio between the two light chains. You will have imaging studies to evaluate for bone or other abnormalities. These studies could include X-rays, MRI, CT, and/or PET-CT imaging.

May 1, 1988 · The La (SS-B) polypeptide is a ribonucleoprotein against which high titer antinuclear antibodies (ANA) react in the human autoimmune disease primary Sjögren's syndrome. To identify the autoepitopes with which the ANA anti-La (anti-SS-B) reacts, we isolated a 1.4-kb cDNA clone for La from a lambda gt …

Sep 30, 2021 · ANA are a heterogeneous group that include several different antibodies against specific components of the nucleus and nuclear envelope [1]. We identified 9 cases where there was strong predominance for kappa or lambda light chain stain in the nuclei by immunofluorescence.