Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside .

Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis. They are often used in combination with other antibiotics.

Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans.

Jul 17, 2023 · Although not a new class of antimicrobials, aminoglycosides have continued to prove their clinical value in fighting infections. Aminoglycosides have a broad spectrum of activity covering aerobic organisms, including gram-negative bacteria and mycobacteria.

Optimal bactericidal activity for the aminoglycosides is achieved when the exposure concentration is approximately 8 to 10 times the MIC. Existing data also supports area under the plasma concentration-time curve (AUC) / MIC ratio as an indicator of bacterial killing and efficacy.

Because treatment of enterococcal endocarditis requires prolonged use of a potentially nephrotoxic and ototoxic aminoglycoside plus a bacterial cell wall–active drug (eg, penicillin, vancomycin) to achieve bactericidal synergy, the choice of aminoglycoside must be based on special in vitro susceptibility testing.

Aminoglycosides are a class of antibiotics used to treat serious bacterial infections, such as those caused by gram-negative bacteria (especially Pseudomonas aeruginosa). Spectinomycin is chemically related to aminoglycosides and works in a similar way. It …

Aminoglycoside, any of several natural and semisynthetic compounds that are used to treat bacterial diseases. The term aminoglycoside is derived from the chemical structure of these compounds, which are made up of amino groups (―NH2) attached to …

Aminoglycosides are antibiotics that generally are active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria and principally are used for serious infections.

Oct 25, 2023 · Aminoglycoside antibiotics are a class of potent, broad-spectrum bactericidal agents that have played a critical role in the management of serious bacterial infections for decades.