Feb 8, 2025 · AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. Polyamine synthesis enzyme AMD1 is closely associated with …

Jun 28, 2017 · Mechanistically, this metabolic rewiring stems from mTORC1-dependent regulation of S -adenosylmethionine decarboxylase 1 (AMD1) stability. This novel molecular regulation is …

Mar 28, 2025 · AMD1 (Adenosylmethionine Decarboxylase 1) is a Protein Coding gene. Diseases associated with AMD1 include Developmental And Epileptic Encephalopathy 87 and Sleeping …

Nov 17, 2020 · Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is …

Jan 3, 2018 · Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene …

Apr 22, 2020 · Adenosylmethionine decarboxylase 1 (AMD1) is a key enzyme involved in biosynthesis of polyamines including spermidine and spermine. The potential function of …

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation. Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W. Clin Transl Med. 2021 Mar; …

Title: AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis. AMD1 is required for the maintenance of leukemic stem cells and promotes chronic …

Nov 20, 2020 · Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is …

May 25, 2018 · Mechanistically, this metabolic rewiring stems from mTORC1 (see 601231)-dependent regulation of AMD1 stability. This novel molecular regulation was validated in …