Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated ...
Feb 8, 2018 · One such receptor is MDA5, a viral dsRNA sensor that induces antiviral immune response. Using a newly developed RNase-protection/RNA-seq approach, we demonstrate …
Breaching self-tolerance to Alu duplex RNA underlies MDA5 …
One such receptor is MDA5, a viral dsRNA sensor that induces antiviral immune response. Using a newly developed RNase protection/RNA-seq approach, we here demonstrate that …
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed …
MDA5 disease variant M854K prevents ATP-dependent structural ... - Nature
Nov 18, 2021 · We show that the M854K mutation abrogates ATPase activity, stabilizes MDA5-dsRNA complexes, increases IFN-β transcription, and dampens the cooperativity of signal …
Epigenetic therapy induces transcription of inverted SINEs and …
Oct 21, 2020 · In mammals, the ADAR1 enzyme targets and destabilizes inverted-repeat Alu dsRNA 10, which prevents activation of the MDA5 receptor 11. We found that ADAR1 …
Novel insights into double-stranded RNA-mediated …
Sep 26, 2023 · Activation of the dsRNA-specific immune sensor MDA5 perpetuates the overproduction of type I interferons, and chronic engagement of the interferon-inducible innate …
One such recep-tor is MDA5, a viral dsRNA sensor that induces anti-viral immune response. Using a newly developed RNase-protection/RNA-seq approach, we demon-strate here that …
Cryo-EM Structures of MDA5-dsRNA Filaments at Different
Dec 20, 2018 · Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 …
To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 …
May 13, 2021 · Here, I discuss a role for MDA5 helicase in inducing Z-RNA formation by Alu inverted repeat (AIR) elements. These retroelements have highly conserved sequences that …
ADAR1 prevents autoinflammation by suppressing spontaneous …
Jul 20, 2022 · Mechanistically, adenosine-to-inosine (A-to-I) base modification of endogenous dsRNA by ADAR1 prevents chronic overactivation of the dsRNA sensors MDA5 and PKR 3, 7, …