α-Catenin (alpha-catenin) functions as the primary protein link between cadherins and the actin cytoskeleton. [1] It has been reported that the actin binding proteins vinculin [2] and α-actinin …

In this review, we use cancer data to evaluate molecular models of α-catenin function, from the canonical role of α-catenin in cell-cell adhesion to non-canonical roles identified following …

α-catenin has often been considered to be a non-regulatory intercellular adhesion protein, in contrast to β-catenin, which has well-documented dual roles in cell–cell adhesion and signal …

There are three α-catenin isoforms expressed in mouse and human: αE-catenin (CTNNA1), αN-catenin (CTNNA2), and αT-catenin (CTNNA3). This review summarizes recent progress in …

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. [5][6] αE-catenin is highly expressed in cardiac muscle and localizes to …

Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified [2] became known as α-catenin and β …

Dec 2, 2005 · Here we demonstrate that alpha-catenin exists as a monomer or a homodimer with different binding properties. Monomeric alpha-catenin binds more strongly to E-cadherin-beta …

May 9, 2010 · α-Catenin can respond to myosinII-mediated forces in cell–cell junctions through a force-dependent interaction with vinculin that regulates adherens junction development.

Aug 1, 2014 · Downregulation or loss of α-catenin occurs in multiple human cancer types. The traditional view of α-catenin is that it is one of the core components of the E-cadherin-catenin …

Alpha-catenin has often been considered to be a non-regulatory intercellular adhesion protein, in contrast to beta-catenin, which has well-documented dual roles in cell-cell adhesion and signal …