Alpelisib, sold under the brand name Piqray among others, is a medication used to treat certain types of breast cancer. [8] It is used together with fulvestrant. [8] It is taken by mouth. [8] It is marketed by Novartis. [8]

Mar 7, 2024 · Alpelisib is a targeted therapy from a class of medicines called PI3K inhibitors (phosphoinositide 3-kinase inhibitors) and is sometimes called a kinase inhibitor. Alpelisib is only used for PIK3CA-mutated tumors as detected by an FDA-approved test.

PIQRAY is a kinase inhibitor indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor...

On May 24, 2019, the Food and Drug Administration approved alpelisib (PIQRAY, Novartis Pharmaceuticals Corporation) in combination with fulvestrant for postmenopausal women, and men, with hormone...

PIQRAY® (alpelisib) for the treatment of postmenopausal women, and men, with hormone receptor positive, HER2-negative, advanced breast cancer with a PIK3CA mutation in combination with fulvestrant after disease progression following an endocrine-based regimen.

Alpelisib works by blocking the activity of a protein called PI3K-alpha that signals cells to multiply. It also blocks mutant (overactive) versions of this protein found in cancer cells. This may keep cancer cells from growing and may kill them.

Alpelisib is an oral selective inhibitor of the phosphoinositol-3-kinase (PIK3) which is mutated in several forms of solid tumors and is approved for use in specific forms of advanced or metastatic breast cancer.

Alpelisib is used to treat breast cancer that’s oestrogen receptor positive and HER2 negative and has changes (mutations) in a gene called PIK3CA. It’s given alongside the hormone therapy drug fulvestrant.

Apr 1, 2025 · Alpelisib is used together with other medicines (eg, fulvestrant) to treat hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA­mutated, advanced or metastatic (cancer that has spread) breast cancer.

Alpelisib given with fulvestrant is used to treat breast cancer. What is alpelisib (Piqray®)? Alpelisib belongs to a group of targeted therapy drugs known as cancer growth inhibitors. It is best to read the information about this drug with our general information about targeted therapy drugs and the type of cancer you have.