Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species. This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans.

Jan 1, 2017 · Alloxan is one of the common diabetogenic agents often used to assess the antidiabetic potential of both pure compounds and plant extracts in studies involving diabetes.

Alloxan is synthesized by uric acid oxidation and exerts its diabetogenic action by intravenous, intraperitoneal, or subcutaneous administration. Alloxan evokes insulin release for a short duration inducing complete suppression of the islet response to glucose.

Alloxan is a member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups. It has a role as a hyperglycemic agent and a metabolite. It is functionally related to a barbituric acid. Alloxan has been reported in Euglena gracilis with data available.

Feb 1, 2016 · Alloxan is a thermally stable white solid with an unusual structure. Its formal name is 2,4,5,6(1 H ,3 H )-pyrimidinetetrone, indicating that it has a pyrimidine ring structure with four carbonyl groups.

We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. However, we experienced an inconsistent and unpredictable response with alloxan, similar to that discussed by Jain et al. Healthy adult albino rats (150-200 g) and rabbits (1.5-2.5 kg) were used in the study.

Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species (ROS) in a cyclic redox reaction with its reduc …

Sep 28, 2021 · Alloxan is an important toxic glucose analogue used to induce diabetes in lab test animals. Once regarded as a “problem structure,” the condensed-phase structure of anhydrous alloxan has largely be...

Dec 18, 2024 · Alloxan (CAS 50-71-5) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.

Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas when administered to rodents and many other animal species, and has been shown to cause mitochondrial dysfunction.