Feb 11, 2021 · Chronic lung allograft dysfunction may manifest with a spectrum of imaging and pathologic findings and a combination of obstructive and restrictive functional abnormalities. Awareness of the spectrum of CT findings is important to minimize diagnostic delay and improve patient outcomes.

An initial CT scan is recommended for all patients 6 months after lung transplantation, when spirometry is expected to be optimal . It should be performed without iodine contrast, in high resolution (maximum width of 3-mm sections), at full inspiration and expiration.

Jan 3, 2023 · Chronic lung allograft dysfunction (CLAD) is one of the late-stage post lung transplant complications. It is the most common cause of mortality in lung transplant recipients after the 1 st year of transplantation 4.

May 24, 2018 · The purpose of this article is to review the high-resolution CT characteristics of individual obstructive and restrictive chronic lung allograft dysfunction (CLAD) phenotypes to aid in making accurate diagnoses and guiding treatment.

Aug 26, 2021 · CT angiography is a powerful tool for early detection of vascular complications, which is essential for optimizing the outcomes. Chronic lung allograft dysfunction is the primary limiting factor of long-term survival in patients who have undergone lung transplantation and represents a heterogeneous group of diseases.

Apr 30, 2021 · Recognition of early signs of rejection is crucial for better understanding of physiopathologic pathways and optimal management of patients. Keywords: chronic lung allograft dysfunction; computed tomography (CT) scan; lung transplantation.

Chronic lung allograft dysfunction may manifest with a spectrum of imaging and pathologic findings and a combination of obstructive and restrictive functional abnormalities. Awareness of the spectrum of CT findings is important to minimize diagnostic delay and im …

Jul 1, 2024 · Different CLAD phenotypes have recently been defined, based on the combination of pulmonary function testing and chest computed tomography (CT) scanning and spurred renewed interests in differential diagnosis, risk factors and management of CLAD.

Apr 30, 2021 · If CLAD remains a clinical diagnosis based on spirometry, computed tomography (CT) scan plays an important role in the diagnosis and follow-up of CLAD patients, to exclude identifiable causes of functional decline when CLAD is first suspected, to detect early abnormalities that can precede the diagnosis of CLAD (particularly RAS), to ...

High resolution CT scan may reveal bronchiectasis (sensitivity 64-80%, specificity 78-90%) and air trapping (sensitivity 80-91%, specificity 80-94%) [9, 10]. Pulmonary function testing demonstrates a FEV1 ≤80% of baseline function [5, 11].