Mar 5, 2024 · Ablation of ALKBH5 in CD4 + T cells increases m6A modification on IFN-γ and CXCL2 mRNA and reduces corresponding protein expression, thereby attenuating T cell-mediated inflammation and immune...

Jun 4, 2021 · We find that ROS significantly induces global mRNA N6-methyladenosine (m6A) levels by modulating ALKBH5 post-translational modifications (PTMs), leading to the rapid and efficient induction of thousands of genes involved in a variety of biological processes including DNA damage repair.

Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological ...

Jul 28, 2020 · The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers.

Aug 27, 2024 · Exploring the intricate biological roles of FTO and ALKBH5 sheds light on the regulatory mechanisms of m6A modification within cells and holds promise for devising novel therapeutic interventions for associated disorders.

Oct 16, 2024 · Lactylated ALKBH5 binds interferon-beta (IFN-β) messenger RNA (mRNA), leading to demethylation of its m 6 A modifications and promoting IFN-β mRNA biogenesis. Overexpression of ESCO2 or depletion of SIRT6 further enhances ALKBH5 lactylation to strengthen IFN-β mRNA biogenesis.

Sep 17, 2024 · This study explored the mechanism by which the m6A demethylase ALKBH5 mediates epithelial–mesenchymal transition (EMT) in sepsis-associated acute kidney injury (SA-AKI) and AKI-chronic kidney disease...

5 days ago · ALKBH5 is a well-known m6A demethylase (also called m6A “eraser”) and plays a role in regulating different target genes or m6A modifications in different regions of the same gene . It's proven that m6A demethylase FTO promotes the development of scar tissue by regulating COL1A1 m6A modification, maintaining mRNA stability and upregulating ...

6 days ago · Ectopically expressed ALKBH5 or YTHDF1 knockdown partially reversed the increased ferroptosis in vitro and in vivo, evidenced by decreased levels of Fe 2+, malondialdehyde and reactive oxygen species yet increased glutathione level. ALKBH5 mediated m6A modification of ACSL4 mRNA and disrupted its stability in a YTHDF1-dependent manner.

Here we report ALKBH5 as another mammalian demethylase that oxidatively reverses m 6 A in mRNA in vitro and in vivo. This demethylation activity of ALKBH5 significantly affects mRNA export and RNA metabolism as well as the assembly …