293 users active in the past 15 minutes (3 members, 0 of whom are invisible, and 285 guests). Our members have made a total of 906,481 posts in 251 threads. We currently have 6,835 members registered.

Feb 16, 2018 · To test this hypothesis, we examined an under-explored ALCAM splice variant (ALCAM-Iso2) and demonstrated that loss of the membrane-proximal region of ALCAM (exon 13) increased metastasis...

ALCAM functions as a cell–cell adhesion molecule and engages in homotypic (ALCAM–ALCAM) and heterotypic (ALCAM–CD6) interactions between adjacent cells. These interactions are mediated through its most amino-terminal V domain (D1).

The ALCAMS logo, which is a red silhouette of Alabama with a large hand reaching into the state, and a smaller red hand reaching into the larger hand.

ALCAM is a cell surface glycoprotein structurally related to the immunoglobulin superfamily, with 10 potential N-glycosylation sites in its extracellular domain (ED), a transmembrane and a short cytoplasmic domain.

ALCAM (activated leukocyte cell adhesion molecule) is an important regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has prognostic values depending on cancer types and is also linked to distant metastases.

To better understand how ALCAM might regulate cancer cell behavior, we utilized a panel of defined uveal melanoma cell lines with high or low ALCAM levels, and directly tested the effects of manipulating these levels on cell motility, invasiveness, and adhesion using multiple assays.

ALCAMS is a valuable tool for both teachers and students, offering a range of benefits that can enhance the language learning and assessment process.

We show here that Alcam is differentially regulated in adult hematopoiesis and is highly expressed in LT-HSCs where its level progressively increases with age. Young adult Alcam (-/-) mice had normal homeostatic hematopoiesis and normal numbers of phenotypic HSCs.

Home - ALCAMS. Alabama Child Abuse Medical System (ALCAMS) is a joint effort between COA/UAB and the Alabama Network of Child Advocacy Centers (ANCAC). The ALCAMS mission is to establish, support, and ...