AKT2, also known as RAC-beta serine/threonine-protein kinase, [5] is an enzyme that in humans is encoded by the AKT2 gene. [6] It influences metabolite storage as part of the insulin signal transduction pathway.

Mar 30, 2025 · Complete information for AKT2 gene (Protein Coding), AKT Serine/Threonine Kinase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

AKT regulates glucose and lipid metabolism. Activated AKT2, which is primarily expressed in insulin-responsive tissues, promotes translation of glucose transporter 4 (GLUT4). And the direct target of AKT is a substrate of 160 kDa (AS160), also known as TBC1D1 29.

Feb 8, 2025 · Results suggest that Akt2 directly mediates EGF-induced chemotactic signaling pathways through PKCzeta and its expression is critical during the extravasation of circulating cancer cells. Two variants in 5' regulatory region of Akt2 gene are associated and may modulate susceptibility to insulin resistance and related metabolic abnormalities.

AKT is a central protein in many cellular pathways such as cell survival, proliferation, glucose uptake, metabolism, angiogenesis, as well as radiation and drug response. The three isoforms of AKT (AKT1, AKT2 and AKT3) are proposed to have different ...

Feb 8, 2025 · Title: Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.

Sep 18, 2020 · Our study establishes a new and important function of AKT2 in regulating skeletal muscle development and glucose metabolism via AMPK-dependent signaling. Keywords: AKT2; AMPK; glucose metabolism; mitochondria; skeletal muscle.

Nov 11, 2011 · AKT2 encodes a protein belonging to a subfamily of serine/threonine kinases containing Src homology 2 (SH2)-like domains (Cheng et al., 1992). Staal (1987) cloned AKT1 …

Akt, also known as Protein kinase B (PKB), is a serine-threonine kinase with important roles in proliferation, metabolism, cell differentiation, survival, etc (1, 2). There are three distinct Akt isoforms encoded by three separate genes, namely Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ.

Dec 16, 2020 · Akt2 loss-of-function increased anxiety-like phenotypes, impaired fear conditioned learning, social behaviors and discrimination memory. Reduced sensitivity to amphetamine was observed,...