Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its …
Nuclear Akt associates with p300 and phosphorylates its Ser-1834 both in vivo and in vitro. The phosphorylation induces recruitment of p300 to the ICAM-1 promoter, leading to the …
p38 MAPK- and Akt-mediated p300 phosphorylation regulates its ...
Feb 1, 2013 · In depth, functional analysis revealed that (i) p300 and CBP act redundantly in repairing ultraviolet (UV) lesions, (ii) the phosphorylation of p300 at S1834 is critical for …
P300 Acetyltransferase Mediates Stiffness-Induced Activation of …
In HSCs, substrate stiffness activated AKT signaling via RHOA to induce phosphorylation of p300 at serine 1834; this caused p300 to translocate to the nucleus, where it upregulated …
p38 MAPK- and Akt-mediated p300 phosphorylation regulates its ...
To identify the kinases that are responsible for UV-induced phosphorylation of p300 at S1834, we tested the function of p38 MAPK and Akt in mediating p300 phosphorylation and degradation …
mTORC1 Phosphorylates Acetyltransferase p300 to Regulate …
Oct 19, 2017 · Activated mTORC1 interacts with p300 and phosphorylates p300 at 4 serine residues in the C-terminal domain. Mechanistically, phosphorylation of p300 by mTORC1 …
P300, A New Player in Mechanosensitivity and Activation of …
May 4, 2018 · Increasing matrix rigidity induced the RhoA-Akt-p300 pathway, resulting in p300 nuclear translocation and the expression of smooth muscle α-actin and a panel of tumor …
Akt phosphorylates p300 at Ser-1834 in vitro and in vivo
HA-myr-Akt immunoprecipitated by anti-HA antibody was mixed with wt Flag-p300 or its S1834A mutant extracted from unstimulated cells and then subjected to an in vitro phosphorylation …
Role of p300, a histone acetyltransferase enzyme, in osteoblast ...
Mar 1, 2022 · Akt, a protein kinase B involved in cell survival and anti-apoptotic mechanisms, targets p300 in the Akt-p300 axis (Shafique and Winn, 2020). Maintaining steady-state levels …
Molecular Basis for the Regulation of Transcriptional Coactivator p300 ...
Sep 10, 2015 · Blunting of p300 impairs myogenic expression and myoblast differentiation. Thus, our data suggests a particular role for Akt in myoblast differentiation through interaction with …
Akt phosphorylation of p300 at Ser-1834 is essential for its …
Nuclear Akt associates with p300 and phosphorylates its Ser-1834 both in vivo and in vitro. The phosphorylation induces recruitment of p300 to the ICAM-1 promoter, leading to the …