Sep 10, 2019 · AKT, also named protein kinase B (PKB), is a primary mediator of the PI3K signaling pathway; and ERK at the end of MAPK signaling is the unique substrate and downstream effector of mitogen-activated protein/extracellular signal-regulated kinase (MEK).

Jun 23, 2020 · Finally, ERK and phosphoinositide 3-kinase (PI3K)–AKT signalling were recently shown to stimulate cap-dependent translation of the apoptosis inhibitor BIRC5 (also known as survivin) 108...

Analyzing the crosstalk mechanisms of the RAS-ERK and PI3K/AKT signaling, the authors found that activation of PI3K/AKT after RAS-ERK pathway inhibition required β1 integrin, myosin light chain kinase (MLCK), and myosin IIA.

Jun 4, 2024 · Understanding the dynamics of intracellular signaling pathways, such as ERK1/2 (ERK) and Akt1/2 (Akt), in the context of cell fate decisions is important for advancing our knowledge of cellular...

We then examined the signaling responses resulting from these DSBs. We show here that ATM regulates ERK phosphorylation and we report on a bi-phasic ERK response that could play an important role in determining cellular fate in response to DNA damage and the balance between cell survival and death.

This review has emphasized on involvement of Akt/Erk cascade in the neurodegeneration. Akt has been reported to regulate neuronal toxicity through its various substrates like FOXos, GSK3β, and caspase-9 etc. Akt is also involved with PI3K in …

Previous studies have shown that, in part, Akt and ERK promote mTORC1 signaling through phosphorylation of a GTPase activator protein (GAP), referred to as tuberous sclerosis complex 2 (TSC2), that acts as an upstream inhibitor of mTORC1.

Jul 17, 2020 · The model quantitatively studies particular aspects of FGF and VEGF interactions network in ERK and Akt phosphorylation, provides mechanistic insight into their signaling network, and identifies specific potential angiogenic targets that can be altered to …

Jun 19, 2023 · To analyze potential functions of ERK and AKT dynamics in controlling mouse embryonic stem cell (ESC) fates, we developed ESC lines and experimental pipelines for the simultaneous long-term manipulation and quantification of ERK or AKT dynamics and cell fates.

Previous studies have shown that, in part, Akt and ERK promote mTORC1 signaling through phosphorylation of a GTPase activator protein (GAP), referred to as tuberous sclerosis complex 2 (TSC2), that acts as an upstream inhibitor of mTORC1.