Integrity of the AID serine-38 phosphorylation site is critical for ...
Feb 2, 2009 · These results unequivocally demonstrate that integrity of the AID S38 phosphorylation site is required for normal CSR and SHM in mice and strongly support a role …
Regulation of Activation-Induced Cytidine Deaminase DNA …
Here, we discuss recent biochemical and mouse genetic studies that begin to elucidate the functional significance of AID S38 phosphorylation in the context of the evolution of this mode …
Integrity of the AID serine-38 phosphorylation site is ... - PubMed
Feb 24, 2009 · These results unequivocally demonstrate that integrity of the AID S38 phosphorylation site is required for normal CSR and SHM in mice and strongly support a role …
Activation-induced Cytidine Deaminase in B Cell Immunity and …
Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed in germinal center B cells and plays a pivotal role in immunoglobulin class switch recombination …
Regulation of class switch recombination and somatic mutation by AID …
Oct 10, 2008 · It has been proposed that AID phosphorylation at serine 38 (S38) regulates its activity, but this has not been tested in vivo. Using a combination of mass spectrometry and …
AID could deaminate duplex DNA led to the finding that AID is phosphorylated on serine residue 38 (S38) by protein kinase A (PKA) (16–18). Biochemical studies demonstrated that AID …
Integrity of the AID serine-38 phosphorylation site is critical ... - PNAS
Feb 24, 2009 · These results unequivocally demonstrate that integrity of the AID S38 phosphorylation site is required for normal CSR and SHM in mice and strongly support a role …
AID could deaminate duplex DNA led to the finding that AID is phosphorylated on serine residue 38 (S38) by protein kinase A (PKA) (16-18). Biochemical studies demonstrated that AID …
Integrity of the AID serine-38 phosphorylation site is ... - NASA/ADS
These results unequivocally demonstrate that integrity of the AID S38 phosphorylation site is required for normal CSR and SHM in mice and strongly support a role for AID phosphorylation …
Evolution of Phosphorylation-Dependent Regulation of Activation …
Oct 24, 2008 · Mouse AID (mAID) interaction with RPA and transcription-dependent dsDNA deamination in vitro requires protein kinase A (PKA) phosphorylation at serine 38 (S38), and …