Jan 5, 2011 · Two intermingled hypothalamic neuron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively influence feeding behavior,...

Aug 24, 2016 · Agouti-related protein (AgRP) neurons within the arcuate nucleus (ARC) of the hypothalamus are a molecularly-defined cell type that is particularly important for the control of feeding.

Apr 27, 2015 · To investigate whether elevated AGRP neuron activity transmits a negative-valence signal, we performed flavour preference conditioning using ad libitum fed mice expressing channelrhodopsin-2...

It has been recently reported that activation of AgRP neurons, either by food deprivation or by ChR2-mediated optogenetic stimulation, enhances mouse’s learning for spatial cues associated with food pellets in a Y-maze test 15.

To determine whether AgRP neuron stimulation is sufficient to induce feeding during various appetite-suppressing conditions, we unilaterally injected AAV carrying a Cre-dependent ChR2-mCherry or GFP transgene into male AgRP Cre/+ knock-in mice (Fig. 1A).

Mar 24, 2016 · We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose tissue (BAT). AgRP neuron activation acutely reprograms gene expression in BAT toward a myogenic signature, including increased expression of myostatin.

Feb 2, 2014 · Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric...

Aug 10, 2021 · We find that the hypothalamic orexigenic agouti-related neuropeptide (AgRP) neurons in the arcuate nucleus (ARC) are profoundly activated by cold exposure. The calcium signals in ARC AgRP neurons display an immediate-response pattern in …

Nov 28, 2023 · We find that AgRP neurons projecting to the paraventricular nucleus of the hypothalamus rapidly and robustly reduce inflammation and mediate the majority of hunger’s anti-inflammatory effects.

Dec 1, 2023 · We engineered Agrp-Ires-Cre mice to express channelrhodopsin-2 (ChR2, by crossing with Ai32 mice) or tdTomato (control, by crossing with Ai9 mice) to enable optogenetic stimulation of AgRP neurons. All mice were implanted with chronic gastric catheters for direct delivery of nutrients to the stomach.