Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis.

Apr 1, 2003 · Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse ...

Mar 9, 2024 · Therefore, muscle Agrin emerges as a contributor to the pathogenesis of age-related sarcopenia, and suggest Agrin intervention in muscle holds promise as a novel therapeutic strategy for...

The well-established role of agrin in NMJ development and its presence in the brain elicited investigations of its possible role in synaptogenesis in the brain. Initial studies on the embryonic brain and neuronal cultures of agrin-null mice did not reveal any defects in synaptogenesis.

As an extracellular matrix protein, Agrin plays a critical role in neuromuscular junction formation. Furthermore, recent studies have revealed the role of Agrin in regulating tissue proliferation and regeneration, which contributes to the repair process of injured tissues. An in-depth understanding of the role of Agrin will therefore be of value.

Jun 8, 2020 · A single dose of agrin is capable of reducing ischemia–reperfusion injury and improving heart function, demonstrating that agrin could serve as a therapy for patients with acute MI and potentially heart failure.

Agrin is an extracellular matrix protein belonging to the heterogeneous family of heparan sulfate proteoglycans (HSPGs), which are key molecules involved in skeletal development, hematopoiesis, and inflammation, 1, 2 as well as in leukocyte adhesion and motility. 3 Agrin has been extensively studied in the context of the neuromuscular junction ...

The meaning of AGRIN is grinning. How to use agrin in a sentence.

Agrin is a widely expressed modular proteoglycan that consists of a core protein of ~220kDa with two glycosaminoglycan side chains that carry heparan sulfate and/or chondroitin sulfate.

Beyond agrin's role in inducing AChR aggregation, the function of agrin and ARPs to provide a localized reservoir of growth factors could contribute to the formation and maintenance of the long-lasting synaptic architecture by specifying and …