The adenosine A1 receptor (A1AR) [5] is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand. A 1 receptors are implicated in sleep promotion by inhibiting wake-promoting cholinergic neurons in the basal forebrain. [6] .

Mar 28, 2025 · ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include Parkinson Disease 13, Autosomal Dominant and Parkinson's Disease. Among its related pathways are Purinergic signaling and GPCR downstream signalling.

Feb 8, 2025 · Gene target information for ADORA1 - adenosine A1 receptor (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Adenosine A1 Receptor (ADORA1) is an adenosine receptor particularly relevant to the immunomodulatory process of malignant tumors, with four family members (ADORA1, ADORA2a, ADORA2b and ADORA3) playing regulatory roles in vitro 10-12.

Nov 23, 2009 · In this study, we report a novel dual role of the adenosine A1 receptor (Adora1) as an E2/ERα target and a regulator of ERα transcriptional activity.

Mar 16, 2020 · Tumor ATF3 deletion improves the effect of ADORA1 antagonist treatment of melanoma and NSCLC xenografts. We observe higher ADORA1, lower ATF3, and lower PD-L1 expression levels in tumor tissues from nonresponders …

Apr 11, 2024 · The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A₁-A_2A receptor heteromer formation and function. Crystal structure of the α_1B-adrenergic receptor reveals …

Dec 1, 2020 · ADORA1 serves as an important oncoprotein and a promoter of cell proliferation through PI3K/AKT signaling pathway in hepatocellular carcinoma.

Sep 14, 2016 · Gene target information for ADORA1 - adenosine A1 receptor (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Feb 8, 2025 · The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A1-A2A receptor heteromer formation and function. Crystal structure of the alpha1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.