A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme [4] that in humans is encoded by the ADAMTS2 gene. [5][6] The ADAMTS2 gene is located on the long (q) arm of chromosome 5 at the end (terminus) of the arm, from base pair 178,473,473 to base pair 178,704,934.

Dec 24, 2024 · ADAMTS2 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2) is a Protein Coding gene. Diseases associated with ADAMTS2 include Ehlers-Danlos Syndrome, Dermatosparaxis Type and Overlapping Connective Tissue Disease.

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of procollagen molecules. Learn about this gene and related health conditions.

For example, Drosophila papilin was shown to regulate activity of bovine ADAMTS2 in procollagen processing and to bind fibrillin-1, which interacts with several ADAMTS proteases as well as ADAMTSL2 [18, 19]. The physiological relevance of these interactions is unknown.

ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens.

ADAMTS-2 is a metalloproteinase that plays a key role in the processing of fibrillar procollagen precursors into mature collagen molecules by excising the amino-propeptide.

Dec 10, 2024 · Clinical resource with information about ADAMTS2, A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke., Ehlers-Danlos syndrome, dermatosparaxis type, Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women., Genome ...

Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein.

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of procollagen molecules. Procollagens are the precursors of collagens, which are complex molecules found in the spaces between cells that add strength, support, and stretchiness (elasticity) to many body tissues.

May 1, 2015 · ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers–Danlos syndrome. ADAMTS2 and 3 are regulators of blood vessels homeostasis and lymphangiogenesis. Larger repertoire of substrates and functions are likely for these ADAMTS.