ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins.

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene. [5][6] This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.

Nov 6, 2024 · Immunohistochemistry (IHC) staining from 90 pathologically verified samples proved the positive correlation between ADAM9 and tumor stages and proved the higher expression of ADAM9 correlated...

Mar 30, 2025 · Complete information for ADAM9 gene (Protein Coding), ADAM Metallopeptidase Domain 9, including: function, proteins, disorders, pathways, orthologs, and expression.

Jun 1, 2005 · Here, we show that an alternatively spliced variant of ADAM9 is secreted by hepatic stellate cells and promotes carcinoma invasion. ADAM9-S induced a highly invasive phenotype in several human tumor cell lines in Matrigel assays, and the protease activity of ADAM9-S was required for invasion.

May 16, 2024 · Our findings identify a role for ADAM9 in the innate antiviral response, specifically MDA5-mediated IFN production, which protects against virus-induced cardiac damage, and provide a potential ...

In contrast, the shorter form of the protein is referred to as ADAM9-S and is the secreted form. The immediate cysteine-rich domain, which has an additional 12 amino acids, is lost due to mutation of the group 13 codon to a terminator, causing the loss of the last three regions.

Aug 1, 2024 · ADAM9-S is a secreted protein that lacks the transmembrane and cytoplasmic domains due to the removal of exon 12 from ADAM9 mRNA. It also contains eight unique amino acids (LSLKFHAPF) not present in ADAM9-L.

Jun 1, 2005 · ADAM9-S binds directly to alpha6beta4 and alpha2beta1 integrins on the surface of colon carcinoma cells through the disintegrin domain. ADAM9-S was also able to cleave laminin and promote invasion.

Sep 7, 2021 · We propose that ADAM9 coordinates plasminogen activator-based network for ESCC progression through two major functions of ADAM9: protease activity for increasing tPA expression/activity and nuclear translocation of ADAM9 for suppressing PAI-1 and PGK1 expression (PAI-1 for reducing plasmin and PGK1 for increasing angiostatin), two inhibitory ...