A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene. [5][6] This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family.

Mar 30, 2025 · ADAM8 (ADAM Metallopeptidase Domain 8) is a Protein Coding gene. Diseases associated with ADAM8 include Asthma. Among its related pathways are Innate Immune System and Extracellular matrix organization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity.

Feb 8, 2025 · Blood ADAM 8 is a promising biomarker for early detection of gastric cancer. ADAMs binds to integrins to regulate cell adhesion and migration. ADAM8 is a marker of residual CML cells.

The expression of ADAM8 in brain metastases from various primary malignancies has been investigated, and ADAM8 has been found to be elevated in brain metastases derived from primary breast cancer and to aid transmigration across the endothelium and blood-brain barriers.

Dec 14, 2023 · ADAM8, also known as MS2/CD156a, is one such protease, and due to its structural and functional characteristics, ADAM8 can exert multiple (pathological) functions. Since the functions of ADAM8 go far beyond that of a shedding enzyme, we summarize here all observations made in the context of homeostasis and pathology over the last decades.

A proteinase with a disintegrin and a metalloproteinase domain-8 (ADAM8) has been linked to asthma. To explore whether ADAM8 is a therapeutic target for asthma. We reviewed literature on ADAM8’s function and expression and activities in lungs of ...

Jan 28, 2015 · We show that ADAM8 expression is associated with increased migration and invasiveness of PDAC cells caused by activation of ERK1/2 and higher MMP activities. For biological function, ADAM8...

We propose that in acute inflammatory lung diseases such as pneumonia and ARDS, ADAM8 inhibition might allow fine-tuning of neutrophil responses for therapeutic gain. Keywords: Inflammation, Pulmonology. Keywords: Innate immunity, Neutrophils, Proteases.

ADAM8 was originally cloned from monocytic cells, and its distinct expression pattern indicates possible roles in both immunology and neuropathology. Here we describe our analysis of its biochemical properties.

Feb 8, 2025 · ADAM8 is an allergen-, IL-4-, and IL-13-induced gene in the experimental asthmatic lung. Taken together with the role of ADAM33 in asthma, these results suggest that allergic lung responses involve the interplay of diverse members of the ADAM family.