Mar 30, 2025 · ACVR1B (Activin A Receptor Type 1B) is a Protein Coding gene. Diseases associated with ACVR1B include Pancreatic Cancer and Transposition Of The Great Arteries, Dextro-Looped. Among its related pathways are NF-kappaB Pathway and Human Embryonic Stem Cell Pluripotency.

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. [5] [6] ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. [7]

Feb 8, 2025 · Title: Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration. Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population.

Feb 8, 2025 · ACVR1B functions as a positive regulator of monocyte/macrophage differentiation. ACVR1B knockdown promoted THP-1 proliferation by increasing Rb phosphorylation. Down-regulation reduced p-Smad2/3 and C/EBPalpha, inhibiting monocyte/macrophage differentiation.

The ACVR1B gene encodes an activin A type IB receptor (location: 12q13.13). Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.

Oct 24, 2008 · Zhou et al. (2000) concluded that the truncated ACVR1B isoforms, predominantly expressed in human pituitary adenomas, function as dominant-negative receptors to interfere with wildtype receptor function and block the antiproliferative effect of activin.

Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

The signals of the transforming growth factor β (TGF-β) superfamily play a critical role in follicular development in mammals. ACVR1B/TGFBR1/ACVR1C receptors mediate the signaling of several TGF-β superfamily ligands in granulosa cells.

Jun 27, 2024 · ACVR1B (Activin A Receptor Type 1B) is a gene encoding a transmembrane serine/threonine kinase, which is essential for signaling within the transforming growth factor-beta (TGF-β) superfamily. Activins, dimeric growth and differentiation factors, signal through a complex of type I and type II receptor serine kinases, including ACVR1B.

Sep 18, 2020 · Loss of ACVR1B accelerates growth of mutant KRAS-induced pancreatic IPMNs in mice; this process appears to involve NOTCH4 and loss of p16. ACVR1B suppresses early stages of pancreatic tumorigenesis; the activin signaling pathway therefore might be a therapeutic target for pancreatic cancer.