The acute toxic class method is based on biometric evaluations (2)(3)(4)(5) with fixed doses, adequately separated to enable a substance to be ranked for classification purposes and hazard assessment.

In this study, a comprehensive dataset of 7,385 compounds with their most conservative lethal dose (LD 50) values has been compiled. A combinatorial QSAR approach has been employed to develop robust and predictive models of acute toxicity in rats caused by …

Aug 30, 2019 · In the framework of a new international collaborative project, the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods and the U.S. Environmental Protection Agency’s National Center for Computational Toxicology compiled a large database of rat acute oral LD50 data, with the aim of supporting the development of new comp...

Apr 15, 2022 · Herein, we present the largest assembly to date of manually curated rat acute oral toxicity LD 50 data comprising chemicals with more than one experimentally derived LD 50 value retrieved from multiple international data sources.

The objective of this study was to assess the acute oral median lethal dose following a single oral administration to female Wistar rats followed by a 14-day observation period. The study was performed in rats, because this species has been shown to be suitable

Jun 28, 2022 · Based on the observed variability, we were able to quantify a margin of uncertainty of ±0.24 log10 (mg/kg) associated with discrete in vivo rat acute oral LD50 values. Keywords: in vivo variability; LD50; acute toxicity; establishing confidence.

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Mar 14, 2011 · The method for QSAR modelling of rat acute toxicity based on the combination of QNA (Quantitative Neighbourhoods of Atoms) descriptors, PASS (Prediction of Activity Spectra for Substances) predictions and self-consistent regression (SCR) is presented.

Dec 1, 2010 · Currently, acute oral toxicity is assessed in rats in accordance with the OECD Test Guidelines 420 (OECD, 2001a), 423 (OECD, 2001b), 425 (OECD, 2001c).

In this study, a comprehensive data set of 7385 compounds with their most conservative lethal dose (LD 50) values has been compiled. A combinatorial QSAR approach has been employed to develop robust and predictive models of acute toxicity in rats caused by …