Nov 20, 2020 · Myostatin (MSTN) is a secreted signaling molecule that normally acts to limit skeletal muscle growth (for review, see ref. 1). Mice lacking MSTN exhibit dramatic increases in muscle mass throughout the body, with individual muscles growing to …

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.

MSTN’s discovery launched an extensive effort directed at understanding the molecular and cellular mechanisms underlying MSTN activity with the long-term goal of developing strategies to target this signaling pathway for therapeutic applications.

Includes receptor activation by myostatin (MSTN), an activin (ActA shown), growth/differentiating factor (GDF)11, or bone morphogenic protein (BMP)9. Each number represents the intracellular signaling locations and red dots represent ubiquitin.

Apr 14, 2020 · In this study we observed upregulation of MSTN mRNA (~8 to 10-fold increase) both in the glomeruli and tubulointerstitium in diabetic nephropathy (DN). In DN, immunoreactive MSTN was mainly...

Feb 20, 2021 · Activin receptor (ActR) and follistatin-like (FSTL) genes, which are involved in the Myostatin (Mstn) related TGF-β/Smad signaling pathway, play important roles in regulating the muscle generation, development and growth of muscle in vertebrate.

A similar trend was observed at the level of ActR IIB (MSTN receptor) mRNA expression and the course that MSTN can combine with its type II receptor kinase (ActR IIB) can be inhibited by...

In this review, we describe the transcriptional regulation and receptor binding pathway of MSTN, then introduce the role of MSTN in regulating mitochondrial function and autophagy, review the...

Feb 20, 2021 · Activin receptor (ActR) and follistatin-like (FSTL) genes, which are involved in the Myostatin (Mstn) related TGF-β/Smad signaling pathway, play important roles in regulating the muscle generation, development and growth of muscle in vertebrate.

May 3, 2021 · MSTN’s discovery launched an extensive effort directed at understanding the molecular and cellular mechanisms underlying MSTN activity with the long-term goal of developing strategies to target this signaling pathway for therapeutic applications.